Article
Identification of three novel LRRK2 mutations associated with Parkinson's disease in a Calabrian population.
Journal of Alzheimer's disease : JAD - 1 Jan 2014
Anfossi Maria, Colao Rosanna, Gallo Maura, Bernardi Livia, Conidi M Elena, Frangipane Francesca, Vasso Franca, Puccio Gianfranco, Clodomiro Alessandra, Mirabelli Maria, Curcio Sabrina A M, Torchia Giusi, Smirne Nicoletta, Di Lorenzo Raffaele, Maletta Raffaele, Bruni Amalia C
Abstract excerpt
BACKGROUND: LRRK2 mutations are common in familial and sporadic Parkinson's disease (PD) cases. OBJECTIVE: We present a screening of the most frequently mutated exons of LRRK2 in Calabrian population. METHODS: Eighty-eight PD patients diagnosed according to standard criteria, underwent screening...
Topics
- Aged
- Female
- Genetic Predisposition to Disease
- Genetic Testing
- Genotype
- Humans
- Italy
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged
- Mutation
- Parkinson Disease
- Population Groups