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Article

Acute kidney injury in patients with severe rash on vemurafenib treatment for metastatic melanomas.

The British journal of dermatology - 1 Oct 2013

Regnier-Rosencher E, Lazareth H, Gressier L, Avril M F, Thervet E, Dupin N

Abstract excerpt

Vemurafenib, a selective BRAF (v-raf murine sarcoma viral oncogene homologue B1) kinase inhibitor, is a new targeted biotherapy that improves survival in patients with metastatic melanomas harbouring the BRAF V600E mutation. However, this drug has significant dermatological adverse effects. We report a new severe cutaneous reaction to this drug associated with acute kidney injury (AKI). Four patients presented a...

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Source

Identifiers

PMID: 23909652
DOI: 10.1111/bjd.12555

Genes

BRAF

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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