Article
Iron and proinflammatory cytokines in chronic hepatitis C virus infection.
Biological trace element research - 1 Oct 2013
López-Prieto Javier, González-Reimers Emilio, Alemán-Valls M Remedios, de la Vega-Prieto María José, Abreu-González Pedro, Pelazas-González Ricardo, Hernández-Luis Rubén, Jorge-Ripper Carlos, Santolaria-Fernández Francisco
Abstract excerpt
Steatohepatitis is a common finding in chronic hepatitis C virus (HCV) infection. As in other forms of steatohepatitis, oxidative damage may play an outstanding role. However, there are conflicting results relative to the role of iron on hepatic lipogenesis. Proinflammatory cytokines up-regulate ferritin expression, probably reflecting a defensive mechanism against increased oxidative stress, capable to open haem...
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