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Article

The cup runneth over: lessons from the ever-expanding pool of primary immunodeficiency diseases.

Nature reviews. Immunology - 1 Sept 2013

Milner Joshua D, Holland Steven M

Abstract excerpt

A recent surge in newly described primary immunodeficiencies (PIDs) has highlighted new physiological and pathophysiological pathways that affect the immune system. Furthermore, the study of individuals with PIDs has substantially improved our understanding of basic cellular and signalling pathways in host defence and immune regulation. Single-gene defects can lead to disease manifestations that range from...

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PMID: 23887241
DOI: 10.1038/nri3493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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