Article
Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium.
PloS one - 1 Jan 2013
Grove Megan L, Yu Bing, Cochran Barbara J, Haritunians Talin, Bis Joshua C, Taylor Kent D, Hansen Mark, Borecki Ingrid B, Cupples L Adrienne, Fornage Myriam, Gudnason Vilmundur, Harris Tamara B, Kathiresan Sekar, Kraaij Robert, Launer Lenore J, Levy Daniel, Liu Yongmei, Mosley Thomas, Peloso Gina M, Psaty Bruce M, Rich Stephen S, Rivadeneira Fernando, Siscovick David S, Smith Albert V, Uitterlinden Andre, van Duijn Cornelia M, Wilson James G, O'Donnell Christopher J, Rotter Jerome I, Boerwinkle Eric
Abstract excerpt
Genotyping arrays are a cost effective approach when typing previously-identified genetic polymorphisms in large numbers of samples. One limitation of genotyping arrays with rare variants (e.g., minor allele frequency [MAF] <0.01) is the difficulty that automated clustering algorithms have to accurately detect and assign genotype calls. Combining intensity data from large numbers of samples may increase the...
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