Article
The suitability of P. falciparum merozoite surface proteins 1 and 2 as genetic markers for in vivo drug trials in Yemen.
PloS one - 1 Jan 2013
Al-abd Nazeh M, Mahdy Mohammed A K, Al-Mekhlafi Abdulsalam M Q, Snounou Georges, Abdul-Majid Nazia B, Al-Mekhlafi Hesham M, Fong Mun Y
Abstract excerpt
BACKGROUND: The accuracy of the conclusions from in vivo efficacy anti-malarial drug trials depends on distinguishing between recrudescences and re-infections which is accomplished by genotyping genes coding P. falciparum merozoite surface 1 (MSP1) and MSP2. However, the reliability of the PCR an...
Topics
- Adolescent
- Adult
- Alleles
- Animals
- Anopheles
- Antigens, Protozoan
- Child
- Child, Preschool
- Disease Vectors
- Female
- Genetic Markers
- Heterozygote
- Humans
- Malaria, Falciparum
- Male
- Merozoite Surface Protein 1
- Molecular Typing
- Phylogeography