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Article

The suitability of P. falciparum merozoite surface proteins 1 and 2 as genetic markers for in vivo drug trials in Yemen.

PloS one - 1 Jan 2013

Al-abd Nazeh M, Mahdy Mohammed A K, Al-Mekhlafi Abdulsalam M Q, Snounou Georges, Abdul-Majid Nazia B, Al-Mekhlafi Hesham M, Fong Mun Y

Abstract excerpt

BACKGROUND: The accuracy of the conclusions from in vivo efficacy anti-malarial drug trials depends on distinguishing between recrudescences and re-infections which is accomplished by genotyping genes coding P. falciparum merozoite surface 1 (MSP1) and MSP2. However, the reliability of the PCR analysis depends on the genetic markers' allelic diversity and variant frequency. In this study the genetic diversity of...

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Identifiers

PMID: 23861823
DOI: 10.1371/journal.pone.0067853
PMCID: PMC3701615

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Source receipt: pubmed, retrieved 7 Sept 2026.

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