Article
Hb Icaria-Hb H disease: identification of the Hb Icaria mutation through analysis of amplified DNA.
British journal of haematology - 1 Jun 1990
Efremov G D, Josifovska O, Nikolov N, Codrington J F, Oner C, Gonzalez-Redondo J M, Huisman T H
Abstract excerpt
Hb Icaria-Hb H disease was observed in a Yugoslavian teenager who exhibited moderate anaemia with severe microcytosis and hypochromia and 16% Hb H. Four of his relatives were Hb Icaria heterozygotes; their haematological data were comparable to those with a deletional type of alpha-thalassaemia-2. The patient also had an additional alpha-thalassaemia-1 deletion, an approximately 20.5 kb deletion, common among...
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