Hb Icaria-Hb H disease: identification of the Hb Icaria mutation through analysis of amplified DNA.

doi:10.1111/j.1365-2141.1990.tb02658.x

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Article

Hb Icaria-Hb H disease: identification of the Hb Icaria mutation through analysis of amplified DNA.

British journal of haematology - 1 Jun 1990

Efremov G D, Josifovska O, Nikolov N, Codrington J F, Oner C, Gonzalez-Redondo J M, Huisman T H

Abstract excerpt

Hb Icaria-Hb H disease was observed in a Yugoslavian teenager who exhibited moderate anaemia with severe microcytosis and hypochromia and 16% Hb H. Four of his relatives were Hb Icaria heterozygotes; their haematological data were comparable to those with a deletional type of alpha-thalassaemia-2...

Topics

Adolescent
Adult
Aged
Child
DNA
Female
Gene Amplification
Genes
Globins
Hemoglobin H
Hemoglobins, Abnormal
Humans
Male
Middle Aged
Mutation
Pedigree
Thalassemia

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