Article
Combined use of multiplex ligation-dependent probe amplification and automatic sequencing for identification of KAL1 defects in patients with Kallmann syndrome.
Fertility and sterility - 1 Sept 2013
Montenegro Luciana Ribeiro, Silveira Leticia F G, Tusset Cintia, de Castro Margaret, Versiani Beatriz R, Latronico Ana Claudia, Mendonca Berenice Bilharinho, Trarbach Ericka B
Abstract excerpt
OBJECTIVE: To investigate the role of KAL1 abnormalities in Brazilian patients with Kallmann syndrome. DESIGN: In vitro experiments. SETTING: Academic medical center. PATIENT(S): One hundred fifteen Brazilian patients (98 men) with Kallmann syndrome. INTERVENTION(S): Peripheral blood leukocytes were used to obtain DNA. MAIN OUTCOME MEASURE(S): Direct sequencing and multiplex ligation-dependent probe amplification...
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