Article
Adherence to assigned dosing regimen and sustained virological response among chronic hepatitis C genotype 1 patients treated with boceprevir plus peginterferon alfa-2b/ribavirin.
Alimentary pharmacology & therapeutics - 1 Jul 2013
Gordon S C, Yoshida E M, Lawitz E J, Bacon B R, Sulkowski M S, Davis M, Poordad F, Bronowicki J-P, Esteban R, Sniukiene V, Burroughs M H, Deng W, Dutko F J, Brass C A, Albrecht J K, Rajender Reddy K
Abstract excerpt
BACKGROUND: Adherence to therapeutic regimens affects the efficacy of peginterferon alfa (P) and ribavirin (R) therapy in patients with chronic hepatitis C virus genotype 1. AIM: To determine if medication adherence impacts efficacy [sustained virological response (SVR)] with triple therapy that includes boceprevir (BOC) plus P/R. METHODS: Adherence was determined in two Phase 3 clinical studies with BOC:...
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