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Article

Glutathione and tryptophan metabolism are required for Arabidopsis immunity during the hypersensitive response to hemibiotrophs.

Proceedings of the National Academy of Sciences of the United States of America - 4 Jun 2013

Hiruma Kei, Fukunaga Satoshi, Bednarek Pawel, Pislewska-Bednarek Mariola, Watanabe Satoshi, Narusaka Yoshihiro, Shirasu Ken, Takano Yoshitaka

Abstract excerpt

The hypersensitive response (HR) is a type of strong immune response found in plants that is accompanied by localized cell death. However, it is unclear how HR can block a broad range of pathogens with different infective modes. In this study, we report that γ-glutamylcysteine synthetase GSH1, which is critical for glutathione biosynthesis, and tryptophan (Trp) metabolism contribute to HR and block development of...

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Identifiers

PMID: 23696664
DOI: 10.1073/pnas.1305745110
PMCID: PMC3677473

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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