Proteomic analysis of human spermatozoa proteins with oxidative stress

Abstract excerpt

BACKGROUND: Oxidative stress plays a key role in the etiology of male infertility. Significant alterations in the sperm proteome are associated with poor semen quality. The aim of the present study was to examine if elevated levels of reactive oxygen species cause an alteration in the proteomic profile of spermatozoa. METHODS: This prospective study consisted of 52 subjects: 32 infertile men and 20 normal donors....

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