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Article

Altered expression of miRNAs in a dihydrotestosterone-induced rat PCOS model

15 May 2013

Abstract excerpt

BACKGROUND: The polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine condition characterized by hyperandrogenism, hyperinsulinemia, insulin resistance and chronic anovulation. Regulation and interaction of a multitude of genes required for follicular development are found to be altered in PCOS. MicroRNAs (miRNAs) mediate posttranscriptional gene regulation by binding to the 3´ untranslated...

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PMID: 23675970
DOI: 10.1186/1757-2215-6-36

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