Article
Human and mouse neuroinflammation markers in Niemann-Pick disease, type C1.
Journal of inherited metabolic disease - 1 Jan 2014
Cologna Stephanie M, Cluzeau Celine V M, Yanjanin Nicole M, Blank Paul S, Dail Michelle K, Siebel Stephan, Toth Cynthia L, Wassif Christopher A, Lieberman Andrew P, Porter Forbes D
Abstract excerpt
Niemann-Pick disease, type C1 (NPC1) is an autosomal recessive lipid storage disorder in which a pathological cascade, including neuroinflammation occurs. While data demonstrating neuroinflammation is prevalent in mouse models, data from NPC1 patients is lacking. The current study focuses on identifying potential markers of neuroinflammation in NPC1 from both the Npc1 mouse model and NPC1 patients. We identified...
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