Article
Histone deacetylase inhibitor AR42 regulates telomerase activity in human glioma cells via an Akt-dependent mechanism.
Biochemical and biophysical research communications - 24 May 2013
Yang Ya-Luen, Huang Po-Hsien, Chiu Hao-Chieh, Kulp Samuel K, Chen Ching-Shih, Kuo Cheng-Ju, Chen Huan-Da, Chen Chang-Shi
Abstract excerpt
Epigenetic regulation via abnormal activation of histone deacetylases (HDACs) is a mechanism that leads to cancer initiation and promotion. Activation of HDACs results in transcriptional upregulation of human telomerase reverse transcriptase (hTERT) and increases telomerase activity during cellular immortalization and tumorigenesis. However, the effects of HDAC inhibitors on the transcription of hTERT vary in...
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