Article
Candidate gene studies in hypodontia suggest role for FGF3.
European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry - 1 Dec 2013
Vieira A R, D'Souza R N, Mues G, Deeley K, Hsin H-Y, Küchler E C, Meira R, Patir A, Tannure P N, Lips A, Costa M C, Granjeiro J M, Seymen F, Modesto A
Abstract excerpt
INTRODUCTION: The majority of tooth agenesis cases are mild (hypodontia) and typically not associated with the gene mutations linked to oligodontia. From this, we hypothesise that most cases of tooth agenesis fit a polygenic mode of inheritance, where several genes with small effects cause a variety of varying phenotypes. MATERIALS AND METHODS: In this study, we looked at 18 not typically studied genes in this...
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