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Article

Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors.

Oncogene - 20 Mar 2014

Ducker G S, Atreya C E, Simko J P, Hom Y K, Matli M R, Benes C H, Hann B, Nakakura E K, Bergsland E K, Donner D B, Settleman J, Shokat K M, Warren R S

Abstract excerpt

The mammalian target of rapamycin (mTOR) regulates cell growth by integrating nutrient and growth factor signaling and is strongly implicated in cancer. But mTOR is not an oncogene, and which tumors will be resistant or sensitive to new adenosine triphosphate (ATP) competitive mTOR inhibitors now in clinical trials remains unknown. We screened a panel of over 600 human cancer cell lines to identify markers of...

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Identifiers

PMID: 23542178
DOI: 10.1038/onc.2013.92
PMCID: PMC3982880

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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