Article
Clinical significance of CD33 nonsynonymous single-nucleotide polymorphisms in pediatric patients with acute myeloid leukemia treated with gemtuzumab-ozogamicin-containing chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2013
Mortland Leslie, Alonzo Todd A, Walter Roland B, Gerbing Robert B, Mitra Amit K, Pollard Jessica A, Loken Michael R, Hirsch Betsy, Raimondi Susana, Franklin Janet, Pounds Stanley, Cao Xueyuan, Rubnitz Jeffrey E, Ribeiro Raul C, Gamis Alan, Meshinchi Soheil, Lamba Jatinder K
Abstract excerpt
PURPOSE: The purpose of this study was to evaluate clinical implications of CD33 single-nucleotide polymorphisms (SNP) in pediatric patients with acute myeloid leukemia (AML) treated with gemtuzumab-ozogamicin (GO)-based therapy. EXPERIMENTAL DESIGN: We genotyped four CD33 SNPs: rs35112940 (G>A; Arg304Gly), rs12459419 (C>T; Ala14Val), rs2455069 (A>G; Arg69Gly), and rs1803254 (G>C; 3'UTR) in pediatric patients...