Prediction of mutant mRNA splice isoforms by information theory-based exon definition.

Abstract excerpt

Mutations that affect mRNA splicing often produce multiple mRNA isoforms, resulting in complex molecular phenotypes. Definition of an exon and its inclusion in mature mRNA relies on joint recognition of both acceptor and donor splice sites. This study predicts cryptic and exon-skipping isoforms in mRNA produced by splicing mutations from the combined information contents (R(i), which measures binding-site...

Topics

• Algorithms
• Computational Biology
• Databases, Nucleic Acid
• Exons
• Information Theory
• Molecular Sequence Annotation
• Mutation
• RNA Isoforms
• RNA Splicing
• Regulatory Sequences, Nucleic Acid
• Reproducibility of Results