MicroRNA-34a is a tumor suppressor in choriocarcinoma via regulation of Delta-like1

Abstract excerpt

BACKGROUND: Choriocarcinoma is a gestational trophoblastic tumor which causes high mortality if left untreated. MicroRNAs (miRNAs) are small non protein-coding RNAs which inhibit target gene expression. The role of miRNAs in choriocarcinoma, however, is not well understood. In this study, we examined the effect of miR-34a in choriocarcinoma. METHODS: MiR-34a was either inhibited or ectopically expressed...

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