Article
Functional promoter -308G>A variant in tumor necrosis factor α gene is associated with risk and progression of gastric cancer in a Chinese population.
PloS one - 1 Jan 2013
Hong Yan, Ge Zhijun, Jing Changrui, Shi Jun, Dong Xiao, Zhou Fengying, Wang Meilin, Zhang Zhengdong, Gong Weida
Abstract excerpt
BACKGROUND: Tumor necrosis factor-α (TNF-α) plays a crucial role in the development and progression of gastric cancer. A functional polymorphism, -308 G>A (rs1800629), which is located in the promoter of TNFA gene, has been suggested to alter the production of TNF-α and influence cancer risk. In the present study, we sought to investigate whether this polymorphism has effects on the risk and progression of...
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