Article
Central adrenal insufficiency in young adults with Prader-Willi syndrome.
Clinical endocrinology - 1 Sept 2013
Grugni Graziano, Beccaria Luciano, Corrias Andrea, Crinò Antonino, Cappa Marco, De Medici Clotilde, Di Candia Stefania, Gargantini Luigi, Ragusa Letizia, Salvatoni Alessandro, Sartorio Alessandro, Spera Sabrina, Andrulli Simeone, Chiumello Giuseppe, Mussa Alessandro
Abstract excerpt
OBJECTIVE: A high prevalence (60%) of central adrenal insufficiency (CAI) has been reported in Prader-Willi syndrome (PWS) using the metyrapone test. We have assessed CAI in adults with PWS using the low-dose short synacthen test (LDSST). DESIGN: Basal cortisol and ACTH, and 30-min cortisol after the administration of 1 μg synacthen, were determined in 53 PWS adults (33 females). A peak cortisol value of ≥500...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.