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Article

Telomere Length in Epidemiology: A Biomarker of Aging, Age-Related Disease, Both, or Neither?

1 Jan 2013

Abstract excerpt

Telomeres are nucleoprotein caps flanking DNA. They are shortened by cell division and oxidative stress and are lengthened by the enzyme telomerase and DNA exchange during mitosis. Short telomeres induce cellular senescence. As an indicator of oxidative stress and senescence (2 processes thought to be fundamental to aging), telomere length is hypothesized to be a biomarker of aging. This hypothesis has been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 23302541
DOI: 10.1093/epirev/mxs008

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