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Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development

1 Jan 2013

Abstract excerpt

The rapid accumulation of knowledge on apoptosis regulation in the 1990s was followed by the development of several experimental anticancer- and anti-ischaemia (stroke or myocardial infarction) drugs. Activation of apoptotic pathways or the removal of cellular apoptotic inhibitors has been suggested to aid cancer therapy and the inhibition of apoptosis was thought to limit ischaemia-induced damage. However,...

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PMID: 23301705
DOI: 10.1111/jcmm.12001

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