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The pathobiology of two Indonesian H5N1 avian influenza viruses representing different clade 2.1 sublineages in chickens and ducks.

Comparative immunology, microbiology and infectious diseases - 1 Mar 2013

Wibawa Hendra, Bingham John, Nuradji Harimurti, Lowther Sue, Payne Jean, Harper Jennifer, Wong Frank, Lunt Ross, Junaidi Akhmad, Middleton Deborah, Meers Joanne

Abstract excerpt

To determine the pathobiology of Indonesian H5N1 highly pathogenic avian influenza, two viruses representing clades 2.1.1 and 2.1.3 were inoculated into broiler chickens and Pekin ducks via the eyes, nostrils and oropharynx. In chickens, both viruses produced fulminant disease; tissue tropism was broad but predominantly endothelial and viral loads in tissues were high. Except for one case of meningoencephalitis,...

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Identifiers

PMID: 23290928
DOI: 10.1016/j.cimid.2012.12.001

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