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Article

Rabbit as a novel animal model for hepatitis E virus infection and vaccine evaluation.

PloS one - 1 Jan 2012

Cheng Xianfeng, Wang Song, Dai Xing, Shi Chengbo, Wen Yufeng, Zhu Ming, Zhan Shenwei, Meng Jihong

Abstract excerpt

BACKGROUND: The identification of hepatitis E virus (HEV) from rabbits motivated us to assess the possibility of using rabbits as a non-human primate animal model for HEV infection and vaccine evaluation. METHODOLOGY/PRINCIPAL FINDINGS: First, 75 rabbits were inoculated with seven strains of genotypes 1, 3, 4, and rabbit HEV, to determine the appropriate strain, administrative route and viral dosage. Second, 15...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23272124
DOI: 10.1371/journal.pone.0051616
PMCID: PMC3521758

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