Becker muscular dystrophy: correlation of deletion type with clinical severity.

doi:10.1136/jmg.27.4.236

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Article

Becker muscular dystrophy: correlation of deletion type with clinical severity.

Journal of medical genetics - 1 Apr 1990

Norman A M, Thomas N S, Kingston H M, Harper P S

Abstract excerpt

Molecular deletion screening with cDNA probes from the dystrophin gene was undertaken in patients with Becker muscular dystrophy from 58 separate families. Deletions were found in 41 (71%) of these families. Thirty-four (83%) of the deletions started in the same intron near the centre of the gene...

Topics

Adolescent
Adult
Blotting, Southern
Child
Child, Preschool
Chromosome Deletion
Chromosome Mapping
DNA Probes
Genetic Linkage
Humans
Male
Muscular Dystrophies
Phenotype

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