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Article

Preclinical Alzheimer disease-the challenges ahead.

Nature reviews. Neurology - 1 Jan 2013

Sperling Reisa A, Karlawish Jason, Johnson Keith A

Abstract excerpt

There is growing recognition that the pathophysiological process of Alzheimer disease (AD) begins many years prior to clinically obvious symptoms, and the concept of a presymptomatic or preclinical stage of AD is becoming more widely accepted. Advances in biomarker studies have enabled detection of AD pathology in vivo in clinically normal older individuals. The predictive value of these biomarkers at the...

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Identifiers

PMID: 23183885
DOI: 10.1038/nrneurol.2012.241
PMCID: PMC3643203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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