Article
SMARCB1 protein and mRNA loss is not caused by promoter and histone hypermethylation in epithelioid sarcoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2013
Papp Gergő, Changchien Yi-Che, Péterfia Bálint, Pecsenka Loránd, Krausz Thomas, Stricker Thomas P, Khoor Andras, Donner Ludvik, Sápi Zoltán
Abstract excerpt
About 10% of epithelioid sarcomas have biallelic mutation of the SMARCB1 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily b, member 1) gene resulting in a lack of this nuclear protein. It has been suggested that SMARCB1 may be silenced by epigenetic changes in the remaining 90% of tumors. Thus, we hypothesized that the promoter of SMARCB1 is hypermethylated. We also examined...
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