Article
Human leukocyte antigens and Gaucher disease.
Blood cells, molecules & diseases - 1 Mar 2013
Vairo Filippo, Portela Pâmela, Salim Patrícia H, Jobim Mariana, Netto Cristina, Dorneles Alicia, Mittlestadt Suzana, Jobim Luiz Fernando, Schwartz Ida Vanessa D
Abstract excerpt
BACKGROUND: Gaucher disease (GD) is caused by the reduced activity of lysosomal enzyme glucocerebrosidase, which leads to the accumulation of glucocerebroside in macrophages and a chronic stimulation of the immune system. GD is divided into 3 main types according to the presence or absence of neurological involvement and to its presentation (acute or chronic). Gaucher cells show an increase in their expression of...
Topics
- Adolescent
- Adult
- Alleles
- Case-Control Studies
- Female
- Gaucher Disease
- Gene Frequency
- HLA Antigens
- Humans
- Male
- Middle Aged
- Young Adult