Community detection of long QT syndrome with a clinical registry: an alternative to ECG screening programs?

Abstract excerpt

BACKGROUND: Long QT syndrome (LQTS) prevalence is estimated at 4 of 10,000 based on community electrocardiogram (ECG) screening, about which there is disagreement regarding efficacy, accuracy, cost-effectiveness, and practicality. Family studies of autosomal dominant conditions such as LQTS have revealed 8-9 gene-positive family members per proband. OBJECTIVE: To evaluate a cardiac/genetic registry and family...

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