Article
Characterization of the novel HLA-DQB1*06:48 allele by group-specific sequencing.
International journal of immunogenetics - 1 Aug 2013
Foster L, Tate D, Poulton K
Abstract excerpt
HLA-DQB1*06:48 has single nucleotide polymorphisms within codons 70 and 62 of exon 2 (GGG>AGG and AAG>AAC) relative to HLA-DQB1*06:02:01 and HLA-DQB1*06:37. This results in amino acid differences (G>R and K>N) that will change the polarity and charge of the encoded antigen and may therefore affect its peptide repertoire.
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