Article
Inoperable bulky melanoma responds to neoadjuvant therapy with vemurafenib.
BMJ case reports - 22 Oct 2012
Fadaki Niloofar, Cardona-Huerta Servando, Martineau Lea, Thummala Suresh, Cheng Shih-Tsung, Bunker Steve R, Garcia-Kennedy Richard, Wang Wei, Minor David, Kashani-Sabet Mohammed, Leong Stanley P L
Abstract excerpt
A patient with a bulky inoperable stage IIIC melanoma involving the left axilla and neck from a primary of the left medial elbow received vemurafenib as neo-adjuvant treatment. Based on the molecular analysis, BRAF V600E mutation was present. After 4 months of vemurafinib treatment, the tumours shrank to less than 50% of original clinical size and allowed the surgeons to perform a left modified radical neck...
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