Article
Thirty-years of screening for cystic fibrosis in East Anglia.
Archives of disease in childhood - 1 Dec 2012
Calvin Jacqui, Hogg Sarah L, McShane Donna, McAuley Sharon Anne, Iles Richard, Ross-Russell Robert, MacLean Fiona M, Heeley Mary E, Heeley Anthony F
Abstract excerpt
BACKGROUND: Newborn screening for cystic fibrosis (CF) relies on the measurement of immunoreactive trypsinogen (IRT) originating from the pancreas. The Norfolk, Suffolk and Cambridgeshire screening programme initially exploited the persistent increase in IRT seen in CF (IRT-IRT protocol) and later changed to include mutation analysis as a second tier test (IRT-DNA-IRT protocol). RESULTS: During a 30 year period...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.