Article
Vemurafenib: the first drug approved for BRAF-mutant cancer.
Nature reviews. Drug discovery - 1 Nov 2012
Bollag Gideon, Tsai James, Zhang Jiazhong, Zhang Chao, Ibrahim Prabha, Nolop Keith, Hirth Peter
Abstract excerpt
The identification of driver oncogenes has provided important targets for drugs that can change the landscape of cancer therapies. One such example is the BRAF oncogene, which is found in about half of all melanomas as well as several other cancers. As a druggable kinase, oncogenic BRAF has become a crucial target of small-molecule drug discovery efforts. Following a rapid clinical development path, vemurafenib...
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