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Article

Insulin upregulates the expression of zinc finger and BTB domain-containing 7A in HepG2 cells.

Molecular medicine reports - 1 Dec 2012

Tian Jing, Jiang Yuyang

Abstract excerpt

Zinc finger and BTB domain-containing 7A (Zbtb7A) is a proto-oncogene overexpressed in numerous cancers. In this study, we explored the mechanism of insulin-induced Zbtb7A expression. Real-time PCR and western blotting were used to detect Zbtb7A expression. Zbtb7A promoter activity was monitored by Luciferase reporter assay. It was shown that insulin elevates the mRNA and protein levels of the Zbtb7A gene in...

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PMID: 23027183
DOI: 10.3892/mmr.2012.1113

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