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Proinflammatory cytokine IL-1 β polymorphisms in sudden sensorineural hearing loss.

Immunopharmacology and immunotoxicology - 1 Feb 2013

Um Jae-Young, Jang Chul-Ho, Kim Hye-Lin, Cho Young-Bum, Park Jinbong, Lee Seung Joo, Kim Yoon Bum, Kim Hyun-Ju, Ahn Kwang Seok, Jang Hyeung-Jin, Lee Seok-Geun, Lee Hyejung, Lee Kang-Min, Kim Su-Jin, Hong Seung-Heon

Abstract excerpt

The cause and pathogenesis of sudden sensorineural hearing loss (SSNHL) remain unknown. IL-1β is one of the most powerful inflammatory cytokines. The aim of this study was to evaluate the relationships between interleukin-1 β (IL-1β) gene polymorphisms (-511 C/T and +3953 C/T) in patients with SSNHL. One hundred two patients affected by SSNHL and 595 controls were genotyped for IL-1β gene polymorphisms. The...

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PMID: 23013363
DOI: 10.3109/08923973.2012.719523

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