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Article

Unifying the spatial epidemiology and molecular evolution of emerging epidemics

27 Aug 2012

Abstract excerpt

We introduce a conceptual bridge between the previously unlinked fields of phylogenetics and mathematical spatial ecology, which enables the spatial parameters of an emerging epidemic to be directly estimated from sampled pathogen genome sequences. By using phylogenetic history to correct for spatial autocorrelation, we illustrate how a fundamental spatial variable, the diffusion coefficient, can be estimated...

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PMID: 22927414
DOI: 10.1073/pnas.1206598109

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