Article
Charcot-Marie-Tooth disease and related genetic neuropathies.
Continuum (Minneapolis, Minn.) - 1 Feb 2012
Patzko Agnes, Shy Michael E
Abstract excerpt
PURPOSE OF REVIEW: The inherited peripheral neuropathies are a complex group of disorders caused by mutations in more than 50 genes. Scientifically, these disorders provide extensive information on molecular pathways that cause demyelination, axonal loss, and abnormal interactions between Schwann cells and the axons they ensheathe. Clinically, however, these neuropathies are confusing because it is difficult to...
Topics
- Adult
- Charcot-Marie-Tooth Disease
- Child
- Female
- Genetic Predisposition to Disease
- Hereditary Sensory and Motor Neuropathy
- Humans
- Male
- Middle Aged
- Pedigree