The IVS-II-837 (T>G) appears to be a relatively common 'rare' β-globin gene mutation in β-thalassemia patients in Karnataka State, South India.

Abstract excerpt

β-Thalassemia (β-thal) is a common single gene autosomal recessive disorder resulting in severe anemia due to reduced or absent β-globin polypeptide synthesis. The disease is caused by mutations in the β-globin gene; eight common mutations are proposed to cause the majority of β-thal in India. However, the occurrence of a region-specific mutation spectrum in India has also been suggested. We had earlier carried...

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