Article
Current epidemiology and growing resistance of gram-negative pathogens.
The Korean journal of internal medicine - 1 Jun 2012
Livermore David M
Abstract excerpt
In the 1980s, gram-negative pathogens appeared to have been beaten by oxyimino-cephalosporins, carbapenems, and fluoroquinolones. Yet these pathogens have fought back, aided by their membrane organization, which promotes the exclusion and efflux of antibiotics, and by a remarkable propensity to recruit, transfer, and modify the expression of resistance genes, including those for extended-spectrum β-lactamases...
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