Modulating the microbial colonization of the gastrointestinal tract by oral administration of defined Escherichia coli strains. I. Influencing the biotope by means of metabolic drift mutants of Escherichia coli.

Abstract excerpt

Through the selection of spontaneous metabolic drift mutants (selection marker RifR) of an Escherichia coli strain (O6:H2 SmR) of known settling capacity in conventional mice, it was attempted to obtain clones with positively optimized in vitro characteristics, which may exert a promotive influence upon the in vivo colonizing behaviour. Using 512 drift mutant strains (E. coli O6:H2 SmR RifR) we were able to...

Topics

• Administration, Oral
• Animals
• Digestive System
• Escherichia coli
• Hemagglutination
• Immunoglobulin A, Secretory
• Male
• Mice
• Mice, Inbred ICR
• Mucus
• Mutation