Defective lipoprotein sorting induces lolA expression through the Rcs stress response phosphorelay system.

doi:10.1128/JB.00553-12

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Article

Defective lipoprotein sorting induces lolA expression through the Rcs stress response phosphorelay system.

Journal of bacteriology - 1 Jul 2012

Tao Kazuyuki, Narita Shin-Ichiro, Tokuda Hajime

Abstract excerpt

The Escherichia coli LolA protein is a lipoprotein-specific chaperone that carries lipoproteins from the inner to the outer membrane. A dominant negative LolA mutant, LolA(I93C/F140C), in which both (93)Ile and (140)Phe are replaced by Cys, binds tightly to the lipoprotein-dedicated ABC transporter LolCDE complex on the inner membrane and therefore inhibits the detachment of outer membrane-specific lipoproteins...

Topics

Escherichia coli
Escherichia coli Proteins
Gene Expression Regulation, Bacterial
Lipoproteins
Mutation
Periplasmic Binding Proteins
Stress, Physiological
Transcription Factors

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Open in PubMed Open full text

Identifiers

PMID: 22563052
DOI: 10.1128/JB.00553-12
PMCID: PMC3393486

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