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Article

Familial Lund frontotemporal dementia caused by C9ORF72 hexanucleotide expansion.

Neurobiology of aging - 1 Aug 2012

Englund Elisabet, Gustafson Lars, Passant Ulla, Majounie Elisa, Renton Alan E, Traynor Bryan J, Rohrer Jonathan D, Mok Kin, Hardy John

Abstract excerpt

Frontotemporal dementia (FTD) as an important clinical entity was rediscovered in Lund and Manchester in the early 1990s. Here we show that the large Lund pedigree with behavioral variant of frontotemporal dementia previously described with this disorder has an expansion in the recently described C9ORF72 locus on chromosome 9.

Topics

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C9orf72 Protein
Frontotemporal Lobar Degeneration
Genetic Markers
Pedigree
Prevalence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Repetitive Sequences, Nucleic Acid

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Identifiers

PMID: 22483864
DOI: 10.1016/j.neurobiolaging.2012.02.019
PMCID: PMC4562220

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