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Digital PCR analysis of maternal plasma for noninvasive detection of sickle cell anemia.

Clinical chemistry - 1 Jun 2012

Barrett Angela N, McDonnell Thomas C R, Chan K C Allen, Chitty Lyn S

Abstract excerpt

BACKGROUND: Cell-free fetal DNA (cffDNA) constitutes approximately 10% of the cell-free DNA in maternal plasma and is a suitable source of fetal genetic material for noninvasive prenatal diagnosis (NIPD). The objective of this study was to determine the feasibility of using digital PCR for NIPD in pregnancies at risk of sickle cell anemia. METHODS: Minor-groove binder (MGB) TaqMan probes were designed to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22451622
DOI: 10.1373/clinchem.2011.178939

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HBB

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