Article
Rapid and sensitive techniques for identification and analysis of 'reactive-centre' mutants of C1-inhibitor proteins contained in type II hereditary angio-oedema plasmas.
The Biochemical journal - 1 Nov 1990
Aulak K S, Harrison R S
Abstract excerpt
Novel procedures for structural analysis of the 'reactive-centre' residues, particularly the P1 residue, of the dysfunctional C1-inhibitor proteins found in the plasmas of type II hereditary angio-oedema (HAE) patients are described. C1-inhibitor is adsorbed directly from plasma on to Sepharose-a...
Topics
- Angioedema
- Codon
- Complement C1 Inactivator Proteins
- Cysteine
- Histidine
- Humans
- Mutation
- Peptide Fragments
- Sepharose
- Trypsin