Article
Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease.
The Journal of clinical investigation - 1 Nov 1990
Dinauer M C, Pierce E A, Bruns G A, Curnutte J T, Orkin S H
Abstract excerpt
A membrane-bound cytochrome b, a heterodimer formed by a 91-kD glycoprotein (heavy chain) and a 22-kD polypeptide (light chain), is an essential component of the phagocyte NADPH-oxidase responsible for superoxide generation. Cytochrome b is absent in two subgroups of chronic granulomatous disease...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Chromosome Mapping
- Chromosomes, Human, Pair 16
- Cloning, Molecular
- Cytochrome b Group
- Exons
- Genes, Recessive
- Granulomatous Disease, Chronic
- Humans
- Hybrid Cells
- Introns
- Molecular Sequence Data