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Article

The impact of obesity on oocytes: evidence for lipotoxicity mechanisms

5 Dec 2011

Abstract excerpt

Obesity can have detrimental effects on pregnancy rates in natural conceptions and also in women undergoing IVF or intracytoplasmic sperm injection (ICSI). This review summarises the most recent clinical literature investigating whether obesity impacts oocyte quality and early embryo growth. In other tissues, obesity leads to lipotoxicity responses including endoplasmic reticulum stress, mitochondrial dysfunction...

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Identifiers

PMID: 22394715
DOI: 10.1071/rd11904

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