Article
Aspects of liver pathology in adult patients with MDR3/ABCB4 gene mutations.
Virchows Archiv : an international journal of pathology - 1 Mar 2012
Wendum Dominique, Barbu Véronique, Rosmorduc Olivier, Arrivé Lionel, Fléjou Jean-François, Poupon Raoul
Abstract excerpt
The aims of this study were to describe the histological liver lesions in adult patients with MDR3/ ABCB4 mutation and to study the usefulness of MDR3 immunostaining as a diagnostic tool. All adult patients from our institution with an MDR3/ABCB4 mutation and a liver histology were included (n = 13). Eleven patients had a single heterozygous gene mutation and two patients had two heterozygous mutations. Two...
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