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Article

Adrenocortical Cancer in Carney Complex: A Paradigm of Endocrine Tumor Progression or an Association of Genetic Predisposing Factors?

1 Feb 2012

Abstract excerpt

Carney complex (CNC) was described in 1985 as “the complex of myxomas, spotty pigmentation, and endocrine overactivity” (1). The most frequent manifestations of CNC are lentiginosis, myxomas, and ACTH-independent Cushing's syndrome due to primary pigmented nodular adrenocortical disease (PPNAD). PPNAD is a unique cause of adrenal Cushing syndrome in which bilateral pigmented micronodules are typically visible at...

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PMID: 22312093
DOI: 10.1210/jc.2011-3327

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