Double transformation of a hematopoietic malignancy and severe associated thrombopathy. Case presentation and review of the literature.

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Article

Double transformation of a hematopoietic malignancy and severe associated thrombopathy. Case presentation and review of the literature.

Romanian journal of internal medicine = Revue roumaine de medecine interne - 1 Jan 2011

Cişleanu Diana, Onisâi Minodora, Vlădăreanu Ana-Maria, Găman Mihaela, Neagul Ana-Maria, Bumbea H, Iova Anamaria, Baluţa Cristina, Cazaceanu Oana, Begu Mădălina, Ilea Anca

Abstract excerpt

We present the case of a patient with a double transformation during the evolution of chronic hematopoietic malignancy - JAK2 positive chronic myeloproliferative neoplasm; the first transformation had occurred previous to the presentation in our Department, but the second transformation was observed in evolution and it was into a rapidly evolving disease, followed by survival of less than one month. We underline...

Topics

Aged, 80 and over
Antineoplastic Agents
Biomarkers
Cell Transformation, Neoplastic
Chronic Disease
Fatal Outcome
Humans
Janus Kinase 2
Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mutation

Platelet Count

Polycythemia Vera

Primary Myelofibrosis

Prognosis

Pulmonary Embolism

Risk Factors

Splenomegaly

Source

Open in PubMed

Identifiers

PMID: 22303605

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Double transformation of a hematopoietic malignancy and severe associated thrombopathy. Case presentation and review of the literature.PMID 22303605Read ↗

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